Close Menu

    Subscribe to Updates

    Get the latest creative news from FooBar about art, design and business.

    What's Hot

    Nu-Tek BioSciences Showcases Animal-Free Ingredients Driving Pharma Innovation at CPhI Global 2025

    October 2, 2025

    Semtech Launches 1.6T Multimode Optical Solutions for AI Data Centres

    October 1, 2025

    US Government Shutdown 2025: Why It’s Happening and Who’s Impacted

    September 30, 2025
    Facebook X (Twitter) Instagram LinkedIn
    • About Us
    • Press Release
    Thursday, October 2
    Facebook X (Twitter) LinkedIn Instagram
    Business Leaders Review: Best Business Magazine and News OnlineBusiness Leaders Review: Best Business Magazine and News Online
    • Home
    • Magazines
    • Featured Leaders
    • Technology
      • Big Data
      • Artificial Intelligence
      • Robotics
      • Cloud
      • Cyber Security
      • Storage
      • IoT
      • Blockchain
      • Data Analytics
    • Industry
      • Banking & Finance
      • Construction
      • Digital Marketing
      • Economy
      • Education
      • EV Industry
      • Food & Beverage
      • Healthcare
      • Legal
      • Manufacturing
      • Mining & Metals
      • Pharmaceutical
    • Testimonials
    • Events
    • Blogs
    • Awards
    • Our Clients
    Business Leaders Review: Best Business Magazine and News OnlineBusiness Leaders Review: Best Business Magazine and News Online
    Home » Understanding the mechanism of base editing and its impact on DNA repair in blood cells
    Biotechnology

    Understanding the mechanism of base editing and its impact on DNA repair in blood cells

    By Business Leaders ReviewMay 8, 2023

    Specialists Harness Genome Editing Technology for Blood Cell Biology Research.

    In a groundbreaking study published in Cell, experts have employed an exceptionally precise genome-editing technology known as base editing to perform numerous targeted modifications on blood stem cells derived from patients’ bone marrow.

    Gateway to Different Venues to Deepen Knowledge

    This pioneering work marks the first instance of high-throughput base editing, a technique capable of making multiple single-base changes in DNA across multiple cells simultaneously, being applied to blood stem cells. The research team demonstrated how these precise alterations at the nucleotide level within genes can impact the biology of blood cells and offer potential treatments for conditions such as sickle cell anemia and leukemia. These findings open up avenues for researchers to deepen their understanding of the role gene variants play in various diseases affecting different cell types.

    A New Approach to Find Breakthrough

    Vijay Sankaran, a senior author of the study and an associate member at the Broad Institute of MIT and Harvard, expressed, “Our approach not only helps us determine whether a specific gene is implicated in a human disease but also sheds light on the precise molecular mechanisms underlying individual changes to that gene. This breakthrough provides us with a new roadmap for comprehending disease onset and devising effective treatments.”

    Sankaran, who holds the Lodish Family Seat at Boston Children’s Hospital, serves as the Jan Ellen Heaven, MD Professor of Pediatrics at Harvard Medical School, and is a New York Stem Cell Robertson Investigator. He spearheaded this collaborative effort alongside Ramnik Xavier, a distinguished member of the Broad Institute and other associates. The study’s first author, Jorge Diego Martin-Rufino, is a Ph.D. candidate in Sankaran’s laboratory.

    Collaboration of Success

    “Conducting experiments based on disease-causing processes is essential for impacting patients suffering from blood disorders,” stated Xavier, who is also the Kurt J. Isselbacher Professor of Medicine at Harvard Medical School, the director of the Center for Computational and Integrative Biology, and a core member in the Department of Molecular Biology at Massachusetts General Hospital. “This remarkable collaboration among bench scientists, biotechnologists, and physicians has paved the way for identifying disease-associated variants in relevant cell types associated with blood disorders.”

    By leveraging the power of base editing and gene regulation, this study represents a significant step forward in blood cell biology research. The utilization of CRISPR gene-editing technology has opened up new possibilities for genome editing, enabling scientists to explore the intricacies of gene function and its impact on various diseases. The results of this study not only advance our knowledge of blood cell biology but also provide crucial insights for the development of targeted therapies and precision medicine approaches.

    Related Posts

    Nu-Tek BioSciences Showcases Animal-Free Ingredients Driving Pharma Innovation at CPhI Global 2025

    October 2, 2025

    Semtech Launches 1.6T Multimode Optical Solutions for AI Data Centres

    October 1, 2025

    US Government Shutdown 2025: Why It’s Happening and Who’s Impacted

    September 30, 2025

    Trump’s Import Probe Triggers Fall in U.S. Medtech Stocks

    September 27, 2025

    Teleport Enhances Identity Security with AI-Powered Session Summaries

    September 27, 2025

    Next-Generation Humanoid Robot Stuns the World With a Perfect Moonwalk

    September 25, 2025
    Top Posts

    Nu-Tek BioSciences Showcases Animal-Free Ingredients Driving Pharma Innovation at CPhI Global 2025

    October 2, 2025

    Semtech Launches 1.6T Multimode Optical Solutions for AI Data Centres

    October 1, 2025

    US Government Shutdown 2025: Why It’s Happening and Who’s Impacted

    September 30, 2025
    Don't Miss

    Nu-Tek BioSciences Showcases Animal-Free Ingredients Driving Pharma Innovation at CPhI Global 2025

    October 2, 2025

    Key Highlights Nu-Tek BioSciences, a leader in animal-free peptones and specialty yeast extracts, has announced…

    Semtech Launches 1.6T Multimode Optical Solutions for AI Data Centres

    October 1, 2025

    US Government Shutdown 2025: Why It’s Happening and Who’s Impacted

    September 30, 2025

    AI in the Workplace: How AI and Demographic Shifts Are Redefining the Future of Work

    September 27, 2025
    Stay In Touch
    • Facebook
    • Twitter
    • Instagram
    • LinkedIn
    About Us
    About Us

    Business Leaders Review is a global print and digital monthly and yearly magazine, which provides a platform to showcase business/tech leaders and their company’s profile from various sectors. Our aim is to publish the c-suite leaders stories.

    We are helping the leaders & readers to showcase their ideas and innovations to the business and tech world in this current market situation along with their awards and achievements. Doing so we hope to leverage thousands of businesses and personnel around the globe.

    Most Popular

    Nu-Tek BioSciences Showcases Animal-Free Ingredients Driving Pharma Innovation at CPhI Global 2025

    Semtech Launches 1.6T Multimode Optical Solutions for AI Data Centres

    US Government Shutdown 2025: Why It’s Happening and Who’s Impacted

    Latest Magazines
    Facebook X (Twitter) LinkedIn Instagram
    • Home
    • Our Clients
    • TECHNLOGY NEWS
    • Industry News
    • Contact Us
    • Privacy Policy
    • Reprints and Permissions
    © 2021-2025 Business Leaders Review LLC | All Rights Reserved | Empowering Communication Globally

    Type above and press Enter to search. Press Esc to cancel.